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The Fertility Show

Glossary

Xenotransplantation

The transplantation of living cells, tissues or organs from one species to another, for example the transplantation of animal organs into human patients.



Articles using this Glossary Item

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Pig organ transplants a step closer as CRISPR removes viruses

14 August 2017 - by Cara Foley

Ancient viral genes have been eliminated from pigs using the genome editing tool CRISPR, according to research... [Read More]

Mouse pancreas grown in rat reverses diabetes

30 January 2017 - by Arit Udoh

Insulin-producing cells from pancreases grown in rats can cure diabetes when transplanted into mice, according to a study... [Read More]

Genome editing and CRISPR: The science of engineering the embryo

18 January 2016 - by Dr Jess Buxton

We report from the third session of the annual conference of the Progress Educational Trust, titled 'Genome Editing and CRISPR: The Science of Engineering the Embryo', which discussed these new technologies and how they might be used in the future... [Read More]

Will organs from GM pigs save our bacon?

02 November 2015 - by Anna Smajdor and Guy Hardwick

The new gene-editing technique CRISPR/Cas9 could remove one of the toughest barriers to the transplantation of pig organs to humans. And it has been suggested that the production of genetically modified (GM) pig organs could end the anguish of those waiting for suitable donors. But is it really a panacea?

CRISPR could make animal-to-human organ transplant safer

19 October 2015 - by Jessica Richardson

Researchers say that the gene-editing technique CRISPR/Cas9 could be used to increase the safety of organ transplantation from pig to human... [Read More]

Organ transplants from pigs within a decade?

10 November 2008 - by Dr Charlotte Maden

New organs from 'designer pigs' could be ready to use in humans within a decade. The hope is to transplant the organs into humans who require them to help solve the problem of the shortage of transplant organs. Lord Robert Winston, the fertility expert from Imperial College... [Read More]

Baboons receive pig kidneys

08 December 2003 - by BioNews

US researchers have managed to transplant kidneys from genetically modified pigs into baboons, a development that could pave the way for animal-to-human organ transplants, Nature magazine reports. Scientists at the Massachusetts General Hospital, US, used kidneys from pigs that have been genetically altered to reduce rejection by the human and... [Read More]

Goldie is a 'knock-out'

20 January 2003 - by BioNews

A miniature piglet lacking both copies of a gene that would cause its organs to be rejected if transplanted into humans has been cloned by a US-based company. While pigs that have had these genes 'knocked-out' have been cloned before, the organs of the miniature pig are similar in size... [Read More]

Concerns over pig-human fusion cells

16 January 2003 - by BioNews

US scientists have found that human cells injected into a pig fetus can fuse with pig cells, forming 'hybrid' cells that contain genetic material from both species. The surprising findings have implications for research into the use of animal organs for human transplants (xenotransplantation). They might also help explain how... [Read More]

More trouble at PPL

23 September 2002 - by BioNews

PPL Therapeutics, the Scottish-based biotechnology firm responsible for creating Dolly the sheep, announced last week that it is to close the stem cell research side of its business based at Roslin, near Edinburgh, after no buyer had been found for it. In a statement issued by the company, it was... [Read More]

And this little piggy...

27 August 2002 - by BioNews

PPL Therapeutics, the Scottish biotechnology firm behind the creation of Dolly the sheep, has reported that it has produced four cloned piglets which may bring scientists a step closer to being able to use pig organs in human transplants. On Christmas Day last year, a set of piglets was born... [Read More]

The most famous sheep in the world

07 January 2002 - by Juliet Tizzard

We all know that Dolly is the most famous sheep in the world. She is also the only cloned animal that most of us would be able to name. So it comes as no surprise that it is her health, rather than that of any other sheep or any other... [Read More]

This little piggy...

07 January 2002 - by BioNews

A litter of five cloned piglets was born on Christmas Day in Virginia, US. Named Noel, Angel, Star, Joy and Mary, the piglets had also been genetically altered so as to make their organs more compatible for transplant into humans. PPL Therapeutics, the commercial arm of the Roslin Institute which... [Read More]

Uncertainty over animal organ transplants

05 March 2001 - by BioNews

The use of animal organs for human transplant operations (xenotransplantation) is unlikely to solve the organ shortage problem in the near future, according to the third annual report of the UK Xenotransplantation Interim Regulatory Authority (UKXIRA). The report highlights problems with long-term rejection of animal organs by the human immune... [Read More]

New rules for US gene therapy researchers

22 January 2001 - by BioNews

The USA's Food and Drug Administration (FDA) has proposed new regulations for gene therapy researchers, aimed at addressing public concern over the safety of patient trials. Sparked by the outrage that followed the death of teenager Jesse Gelsinger during a gene therapy trial in 1999, the new rules say that... [Read More]

China and Denmark to sequence pig genome

06 November 2000 - by BioNews

Scientists in China and Denmark have formed a consortium to sequence the entire pig genome, reports last week's Science. The partners hope the project - the first of its kind to tackle livestock - will benefit pig-breeding industries in both countries. The information would also help xenotransplantation researchers - the potential use of... [Read More]

India draws up bioethics guidelines

30 October 2000 - by BioNews

The Indian Council of Medical Research (ICMR) has published its first guidelines on biomedical research on human patients, reports the Lancet. They outlaw research on human cloning, germ-line gene therapy (genetic manipulation of egg, sperm or embryo cells) and xenotransplantation (animal to human organ transplants). The guidelines were issued following... [Read More]

Concerns over safety of xenotransplantation

21 August 2000 - by BioNews

A new study has prompted fresh concerns over the safety of xenotransplantation - the use of pig organs for human transplants. A team of researchers based at the Scripps Institute, La Jolla, California, found that mice given pig tissue transplants became infected with pig viruses. Their results are available on Nature's... [Read More]

Pigs cloned using new techniques

21 August 2000 - by BioNews

Two research groups reported successfully cloning pigs last week, using two different variations of the technique used to clone Dolly the sheep. A team based at the National Institute of Animal Industry, Japan, published details of the method it used to clone a pig - called Xena - from an embryo cell... [Read More]

Dolly firm seeks partner

17 April 2000 - by BioNews

PPL Therapeutics, the UK firm responsible for cloning Dolly the sheep and the five piglets born last month, is seeking a new partner to develop its first genetically engineered medicine. Ron James, head of PPL, said talks were underway with three 'global players' and five smaller, more specialised drug companies... [Read More]

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Published by the Progress Educational Trust

CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Jacques Cohen

Dr Anna Smajdor

Dr Andy Greenfield

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross


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