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Human Clinical Embryology and Assisted Conception MSc

Glossary

Mutation

A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic disorder). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.



Articles using this Glossary Item

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Early-onset Parkinson's gene identified

05 December 2016 - by Lone Hørlyck

Researchers have identified a gene linked to early-onset Parkinson's disease... [Read More]

Stress could trigger heart disease linked to mutation

28 November 2016 - by Dr Özge Özkaya

Gene variants coding for the muscle protein titin cause enlarged hearts in healthy individuals, and stress may trigger carriers to develop heart disease, according to a study... [Read More]

X chromosome may offer females protection against cancer

28 November 2016 - by Anna Leida

Having two copies of the X chromosome may help explain why females get cancer less often than males, according to new research... [Read More]

CRISPR partially restores sight in blind rats

21 November 2016 - by Paul Waldron

Scientists in the US have used a genome-editing technique to partially restore vision in blind rats... [Read More]

Second team corrects sickle-cell mutation using CRISPR

14 November 2016 - by Sarah Gregory

Researchers have had further success using the CRISPR/Cas9 genome-editing technique to repair the mutation that causes sickle-cell anaemia... [Read More]

Therapeutic editing of the human genome – Jewish bioethical perspectives

14 November 2016 - by Dr Avi Lerner

Jewish bioethics may help to broaden the discussion of the ethical concerns that emerge from editing the human genome... [Read More]

Autism link to mutations in mitochondria

07 November 2016 - by Helen Robertson

Children with autism spectrum disorder have twice as many harmful mutations in their mitochondrial DNA as their siblings, a study has found... [Read More]

Book Review: Redesigning Life - How Genome Editing will Transform the World

07 November 2016 - by Annabel Slater

Dr John Parrington thinks the ethics of genome editing should be shaped by scientifically informed public debate, and he hopes his book will provide a starting point... [Read More]

Smokers develop 150 mutations per lung cell

07 November 2016 - by Dr Özge Özkaya

For the first time scientists have quantified the number of mutations caused by the number of cigarettes smoked in a lifetime... [Read More]

Genome editing using nanoparticle technology treats blood disorder

31 October 2016 - by Sarah Gregory

Researchers have developed a novel genome-editing technology to correct the defective gene that causes the blood disorder beta-thalassemia... [Read More]

Genetic basis of schizophrenia unfolds

24 October 2016 - by Isobel Steer

Scientists using a new 3D chromosome-mapping technique have uncovered a genetic connection between schizophrenia and early fetal brain development ... [Read More]

CRISPR success in repairing sickle-cell anaemia mutation

17 October 2016 - by Sarah Gregory

Researchers have used the CRISPR/Cas9 genome-editing technique to correct the mutation that causes sickle-cell anaemia... [Read More]

Mitochondrial replacement therapy and the welfare of the child

17 October 2016 - by Dr Mair Crouch

The announcement of the birth of the first child conceived using mitochondrial donation was unforeseen. Nonetheless, in any country regulation should be required to protect the interests of the child... [Read More]

Cancer risk not linked to stem-cell division rates in organs

10 October 2016 - by Annabel Slater

Cancer risk is not linked to different rates of adult stem-cell division in organs, a study suggests... [Read More]

CRISPR used to investigate non-coding regions of the genome

03 October 2016 - by Helen Robertson

Two teams of researchers have used CRISPR genome editing technology to identify 'non-coding' regions of the genome for the first time... [Read More]

Event Review: Who owns your genome?

03 October 2016 - by Isobel Steer

Do you know who owns your genome? And who, if anyone, would you choose to give your genetic information to? This debate, organised by the British Science Association and supported by Genomics England, covered the cutting-edge issues in genomic ethics and legality... [Read More]

World's first mitochondrial donation baby born

03 October 2016 - by Dr Julia Hill

In a world first, the birth of a baby boy who was conceived using mitochondrial donation has been reported... [Read More]

National gene bank opens in China

26 September 2016 - by Ayala Ochert

China has opened a national gene bank that could ultimately be the world's biggest, eventually housing 300 million genetic samples... [Read More]

Testing, Testing 1, 2, 3: PGS and PGD

26 September 2016 - by Dr Nicoletta Charolidi

There was a captivating debate around the emerging genetic choices, legal framework and ethical issues from the use of PGS (pre-implantation genetic screening) and PGD (pre-implantation genetic diagnosis) at this event produced by the Progress Educational Trust (PET)... [Read More]

Book Review: The Gene – An Intimate History

12 September 2016 - by Sarah Gregory

'The Gene: An Intimate History' is the latest book from Pulitzer Prize-winning author Siddhartha Mukherjee. Taking a similar approach to his previous work 'The Emperor of All Maladies: A Biography of Cancer', Mukherjee interweaves his personal history with a comprehensive and extensive review of the history of genetic research... [Read More]

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Events using this Glossary Item

Testing, Testing 1, 2, 3: PGS and PGD
13 September 2016 6pm (registration), 6.30pm-8.30pm (discussion) Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH
The Progress Educational Trust's FREE-to-attend event about testing and screening human embryos is taking place TOMORROW EVENING - book NOW. The event will be chaired by Dr Sue Avery, with speakers including Dr Tony Gordon, Dr Christine Patch, James Lawford Davies and Professor Michael Parker...
Risk Assessment: Breast Cancer, Prediction and Screening
08 May 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
The second FREE public event in the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' series...
Relative Risk: Breast Cancer and Genetics
03 April 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
LAST CHANCE to book for this coming Thursday's FREE event launching the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' project...
Mutants and What to Do About Them
09 February 2011 7.30pm Conway Hall, Red Lion Square, London WC1R 4RL, UK
The 2011 British Humanist Association/South Place Ethical Society Darwin Day Lecture, given by Armand Marie Leroi...
The Blind-Drunk Mutant Mouse: A Model for Schizophrenia?
19 November 2009 12midday Francis Crick Auditorium, Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ, UK
A discussion introduced by Professor Kay Davies, Head of Physiology, Anatomy and Genetics at the University of Oxford...
Techniques and Applications of Molecular Biology
13 July 2009  Department of Biological Sciences, Gibbet Hill Campus, Gibbet Hill Road, University of Warwick, Coventry CV4 7AL
A course for those who wish to develop their understanding of genetic engineering techniques...


Published by the Progress Educational Trust


RETHINKING THE ETHICS OF EMBRYO RESEARCH
Genome Editing, 14 Days and Beyond

Public Conference
London
7 December 2016

Speakers include

Professor Magdalena Zernicka-Goetz

Dr Kathy Niakan

Professor Sir Ian Wilmut

Lord George Carey

Baroness Mary Warnock

Dr Simon Fishel

Professor Bruce Whitelaw

Professor Alison Murdoch

Professor David Jones

Professor Sarah Franklin

Professor Stephen Wilkinson

BOOK HERE

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