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Glossary

Mutation

A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic disorder). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.



Articles using this Glossary Item

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Gene conferring long-life identified in US Amish community

20 November 2017 - by Charlott Repschlager

A rare genetic mutation leading to longer and healthier lives has been discovered in the US Amish community... [Read More]

Genetic 'sensor' spots and kill cells with key cancer gene

20 November 2017 - by Marcia Costa

A team of scientists in Germany has developed a 'sensor' that detects mutations in the key tumour suppressor gene p53 and then kills potentially cancerous cells... [Read More]

Two couples sue fertility clinic for providing eggs with genetic abnormalities

20 November 2017 - by Nina Chohan

The New York fertility clinic Reproductive Medicine Associates is facing two lawsuits from couples whose children, conceived using donor eggs from the centre, have Fragile X syndrome... [Read More]

BRCA screening could prevent 1000 cases of breast cancer a year

13 November 2017 - by Dr Loredana Guglielmi

Researchers have introduced new criteria to screen for BRCA gene mutations that could prevent more than 10,000 cases of cancer and save more than 2000 lives in the next decade... [Read More]

Sick boy gets healthy new skin with genetically-altered stem cells

13 November 2017 - by Paul Waldron

A boy with a rare skin disease has been successfully treated by replacing most of his skin with grafts of stem cells modified by gene therapy.

Twenty-seven genes that suppress cancer discovered

06 November 2017 - by Julianna Photopoulos

Scientists have found 27 new tumour suppressor genes... [Read More]

New advance in DNA base editing tools

30 October 2017 - by Julianna Photopoulos

Scientists have developed the genome editing technique known as 'base editing' to turn adenine-thymine base pairs back to guanine-cytosine... [Read More]

NHS will fund gene therapy for bubble boy syndrome

30 October 2017 - by Jennifer Willows

NICE has approved a gene therapy for children with a rare disorder that leaves them with no functioning immune system... [Read More]

RNA editing tools could create new disease therapies

30 October 2017 - by Dr Rachel Huddart

A new molecular tool to change individual letters in an RNA sequence may open up new possibilities for gene therapy... [Read More]

Number of mutations needed to cause cancer calculated

19 October 2017 - by Charlott Repschlager

Between one and 10 mutations are required for a healthy cell to turn cancerous... [Read More]

FDA advisors back gene therapy for rare inherited blindness

16 October 2017 - by Rikita Patel

The US Food Drug and Administration advisory committee has backed the use of gene therapy to treat a hereditary disease for the first time... [Read More]

Gene test could improve prediction of breast cancer risk

16 October 2017 - by Hannah Somers

A new genetic test to accurately predict an individual's risk of developing breast cancer will soon be rolled out at two hospital clinics in Manchester... [Read More]

Skin colour genes study gives evolutionary insights

16 October 2017 - by Hannah Tippett Simpson

Some dark skin tones have evolved relatively recently from paler genetic variants... [Read More]

'CRISPR-Gold' repairs muscular dystrophy gene in mouse model

09 October 2017 - by Emma Laycock

Scientists have repaired the faulty gene in a mouse model of muscular dystrophy by using gold nanoparticles to deliver the genome editing tool CRISPR-Cas9... [Read More]

Researchers crack how BRCA1 gene raises cancer risk

09 October 2017 - by Dr Loredana Guglielmi

A major breakthrough in understanding how mutations in the BRCA1 gene raise cancer risk has been made by researchers in the USA... [Read More]

Child brain cancer redefined as 10 different diseases

02 October 2017 - by Dr Molly Godfrey

Deadly childhood brain tumours are highly diverse and can be divided into 10 different subtypes, according to new research... [Read More]

CRISPR used to uncover new drug targets for cancer

02 October 2017 - by Rachel Reeves

New potential drug targets have been identified for cancers associated with KRAS gene mutations, which are thought to drive around 20-30 percent of all human cancers... [Read More]

Genome editing targets beta-thalassemia in human embryos

02 October 2017 - by Dr Rachel Brown

A genome editing technique called 'base editing' has been used to correct the mutation causing the inherited blood disorder beta-thalassemia in human embryos... [Read More]

How should we discuss genome editing in public?

02 October 2017 - by Sandy Starr

What do patients and laypeople think and know about genome editing and its implications? What are the best ways for experts and others to discuss genome editing in public, so as to improve public understanding and avoid confusion? The Progress Educational Trust has set out to answer these questions, with its 'Basic Understanding of Genome Editing' project.... [Read More]

Older parents pass down more genetic mutations

25 September 2017 - by Dr Rosie Gilchrist

Parents pass on more new genetic mutations to their children with age, and fathers pass on more than mothers, according to a study... [Read More]

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Events using this Glossary Item

Testing, Testing 1, 2, 3: PGS and PGD
13 September 2016 6pm (registration), 6.30pm-8.30pm (discussion) Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH
The Progress Educational Trust's FREE-to-attend event about testing and screening human embryos is taking place TOMORROW EVENING - book NOW. The event will be chaired by Dr Sue Avery, with speakers including Dr Tony Gordon, Dr Christine Patch, James Lawford Davies and Professor Michael Parker...
Risk Assessment: Breast Cancer, Prediction and Screening
08 May 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
The second FREE public event in the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' series...
Relative Risk: Breast Cancer and Genetics
03 April 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
LAST CHANCE to book for this coming Thursday's FREE event launching the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' project...
Mutants and What to Do About Them
09 February 2011 7.30pm Conway Hall, Red Lion Square, London WC1R 4RL, UK
The 2011 British Humanist Association/South Place Ethical Society Darwin Day Lecture, given by Armand Marie Leroi...
The Blind-Drunk Mutant Mouse: A Model for Schizophrenia?
19 November 2009 12midday Francis Crick Auditorium, Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ, UK
A discussion introduced by Professor Kay Davies, Head of Physiology, Anatomy and Genetics at the University of Oxford...
Techniques and Applications of Molecular Biology
13 July 2009  Department of Biological Sciences, Gibbet Hill Campus, Gibbet Hill Road, University of Warwick, Coventry CV4 7AL
A course for those who wish to develop their understanding of genetic engineering techniques...


Published by the Progress Educational Trust

CROSSING FRONTIERS

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Magdalena Zernicka-Goetz

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Allan Pacey

Dr Sue Avery

Professor Richard Anderson

Dr Elizabeth Garner

Dr Andy Greenfield

Dr Anna Smajdor

Dr Henry Malter

Vivienne Parry

Dr Helen O'Neill

Dr César Palacios-González

Philippa Taylor

Fiona Fox

Sarah Norcross

Sandy Starr


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