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Glossary

Mutation

A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic disorder). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.



Articles using this Glossary Item

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National gene bank opens in China

26 September 2016 - by Ayala Ochert

China has opened a national gene bank that could ultimately be the world's biggest, eventually housing 300 million genetic samples... [Read More]

Testing, Testing 1, 2, 3: PGS and PGD

26 September 2016 - by Dr Nicoletta Charolidi

There was a captivating debate around the emerging genetic choices, legal framework and ethical issues from the use of PGS (pre-implantation genetic screening) and PGD (pre-implantation genetic diagnosis) at this event produced by the Progress Educational Trust (PET)... [Read More]

Book Review: The Gene – An Intimate History

12 September 2016 - by Sarah Gregory

'The Gene: An Intimate History' is the latest book from Pulitzer Prize-winning author Siddhartha Mukherjee. Taking a similar approach to his previous work 'The Emperor of All Maladies: A Biography of Cancer', Mukherjee interweaves his personal history with a comprehensive and extensive review of the history of genetic research... [Read More]

CRISPR shrinks tumours in mice

12 September 2016 - by Dr Özge Özkaya

Scientists from China have managed to shrink the size of tumours in mice using CRISPR/Cas9 genome-editing technology... [Read More]

Simple blood test could be 'smoke detector' for throat cancer

12 September 2016 - by Meetal Solanki

A blood test costing only £35 could help in the early diagnosis of oesophageal cancer and could be available in five years' time... [Read More]

Study brings sickle-cell gene therapy one step closer

12 September 2016 - by Dr Nicoletta Charolidi

A genetically engineered virus that triggers the production of an alternative form of haemoglobin has reversed the symptoms of sickle cell disease in mice... [Read More]

TV Review: My Amazing Twin

05 September 2016 - by Isobel Steer

My Amazing Twin offers a thought-provoking look at both the scientific and the personal side of type 1 neurofibromatosis... [Read More]

Book Review: GMO Sapiens - The Life-Changing Science of Designer Babies

30 August 2016 - by Julian Hitchcock

GMO Sapiens is just the annoying grit in the machine that the genome editing debate needs, but readers deserve clearer lines between science, speculation and opinion... [Read More]

Exome project reveals 3230 disease genes

22 August 2016 - by Dr Barbara Kramarz

More than 3230 genes with the propensity to cause disease have been identified in an analysis of the largest exome dataset yet... [Read More]

Blurred boundaries – the language of DNA

08 August 2016 - by Professor Marcus Pembrey

The general public have appropriated the term DNA to mean much more than just the molecule itself. This may not be a problem most of the time but, in the case of donor eggs and sperm in particular, it's important that people are clear on what genetics and epigenetics really tell us... [Read More]

Gene testing in young patients may uncover 'cancer families'

08 August 2016 - by Amina Yonis

More than half of patients with sarcoma, a rare cancer, have mutations that are known to increase the risk of other types of cancer... [Read More]

Ice-bucket challenge funds ALS gene discoveries

01 August 2016 - by Jenny Sharpe

Donations from the ALS 'ice-bucket challenge' have funded research that has led to the discovery of new genes linked to the disease... [Read More]

New 'obesity gene' found in half of Samoan population

01 August 2016 - by Rachel Reeves

A newly discovered genetic variant in the Samoan population increases obesity risk by 35 percent – the largest effect of any obesity gene... [Read More]

Quick and cheap DNA tests for ovarian cancer patients 'would save lives'

18 July 2016 - by Hannah Somers

Researchers have developed a new pathway for genetically testing ovarian cancer patients which they say will save both lives and money... [Read More]

'Silent' red hair gene increases skin cancer risk

18 July 2016 - by Ayala Ochert

Having a single copy of the 'ginger gene' may increase the risk of skin cancer, even among people who don't have red hair, according to a study... [Read More]

BRCA mutations linked to prostate and uterine cancers

11 July 2016 - by Antony Blackburn-Starza

Genetic mutations on several genes including BRCA2 have been associated with prostate cancer; while in a separate study, a BRCA1 mutation has been linked to a particular form of uterine cancer... [Read More]

Osteoporosis drug touted as potential 'BRCA-blocker'

27 June 2016 - by Helen Robertson

A drug currently used to treat osteoporosis in old age may help prevent breast cancer in women with a genetic predisposition for the disease... [Read More]

Radio Review: Born in Bradford

20 June 2016 - by Professor Sandy Raeburn

The Born in Bradford study, which began in 2007, has recorded data prospectively from 12,000 mothers, 4000 fathers and their 14,000 children born in Bradford General Hospital... [Read More]

Acute myeloid leukaemia made up of 'at least 11 subtypes'

13 June 2016 - by Amina Yonis

A study on the blood cancer acute myeloid leukaemia has shown which combinations of mutations lead to the most aggressive forms of the disease and revealed a complicated picture at the genetic level... [Read More]

Mitochondrial donation is safe, study suggests

13 June 2016 - by Dr Özge Özkaya

An extensive study examining human embryos created using mitochondrial donation has demonstrated that the technique does not adversely affect embryo development... [Read More]

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Events using this Glossary Item

Testing, Testing 1, 2, 3: PGS and PGD
13 September 2016 6pm (registration), 6.30pm-8.30pm (discussion) Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH
The Progress Educational Trust's FREE-to-attend event about testing and screening human embryos is taking place TOMORROW EVENING - book NOW. The event will be chaired by Dr Sue Avery, with speakers including Dr Tony Gordon, Dr Christine Patch, James Lawford Davies and Professor Michael Parker...
Risk Assessment: Breast Cancer, Prediction and Screening
08 May 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
The second FREE public event in the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' series...
Relative Risk: Breast Cancer and Genetics
03 April 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
LAST CHANCE to book for this coming Thursday's FREE event launching the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' project...
Mutants and What to Do About Them
09 February 2011 7.30pm Conway Hall, Red Lion Square, London WC1R 4RL, UK
The 2011 British Humanist Association/South Place Ethical Society Darwin Day Lecture, given by Armand Marie Leroi...
The Blind-Drunk Mutant Mouse: A Model for Schizophrenia?
19 November 2009 12midday Francis Crick Auditorium, Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ, UK
A discussion introduced by Professor Kay Davies, Head of Physiology, Anatomy and Genetics at the University of Oxford...
Techniques and Applications of Molecular Biology
13 July 2009  Department of Biological Sciences, Gibbet Hill Campus, Gibbet Hill Road, University of Warwick, Coventry CV4 7AL
A course for those who wish to develop their understanding of genetic engineering techniques...


Published by the Progress Educational Trust
FROZEN ASSETS?
Preserving Sperm, Eggs and Embryos

FREE event
Edinburgh
25 October 2016

BOOK HERE


RETHINKING THE ETHICS OF EMBRYO RESEARCH
Genome Editing, 14 Days and Beyond

Public Conference
London
7 December 2016

Speakers include

Professor Magdalena Zernicka-Goetz

Dr Kathy Niakan

Professor Sir Ian Wilmut

Lord George Carey

Baroness Mary Warnock

Dr Simon Fishel

Professor Bruce Whitelaw

Professor Alison Murdoch

Professor David Jones

Professor Sarah Franklin

Professor Stephen Wilkinson

BOOK HERE

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