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Preimplantation Genetic Diagnosis: The Who, the What, the Why and the How

Glossary

Mutation

A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic disorder). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.



Articles using this Glossary Item

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Cancer mutations explored using organoids and CRISPR

18 September 2017 - by Dr Molly Godfrey

Organoids and CRISPR/Cas9 have been combined in a novel method to study genetic mutations occurring in cancer... [Read More]

Doubt over human embryo editing study

04 September 2017 - by Annabel Slater

A group of scientists have challenged the landmark study which reported the first successful editing of human embryos for a genetic disease... [Read More]

Podcast Review: Editing the Embryo - removing harmful gene mutations

04 September 2017 - by Eleanor Taylor

As a scientist working in a fertility clinic, my normal everyday work routine is occasionally punctuated by the ripple effect that occurs when reports of a new groundbreaking reproductive technology enters the public consciousness. I am soon inundated with questions... [Read More]

Americans becoming open to human genome editing

21 August 2017 - by Dr Rachel Huddart

A new survey suggests that Americans are becoming more accepting of the use of genome editing in humans, and there is strong support for more public involvement in discussions on the technology... [Read More]

Cancer atlas leads way to personalised treatment

21 August 2017 - by Marcia Costa

Genes linked to 17 types of cancer have been mapped in a new Pathology Atlas by Swedish researchers... [Read More]

Liquid DNA biopsies could be used for cancer screening

21 August 2017 - by Dr Loredana Guglielmi

US researchers have developed a new blood test to detect cancer-related DNA alterations before patients experience symptoms... [Read More]

Vitamin C slows leukaemia in mice by tweaking key gene

21 August 2017 - by Emma Laycock

High doses of vitamin C may help fight certain leukaemias by boosting the activity of a particular gene, suggests a new study... [Read More]

We need to talk about…CRISPR

21 August 2017 - by Giulia Cavaliere

Picture this - it's the last day in the office before the summer holidays, you're looking forward to some sunshine and warmth, email auto-response set, and all ready to go. Then, all of a sudden: the news... [Read More]

Dozens of new gene targets for cancer immunotherapy found

14 August 2017 - by Ebtehal Moussa

Over a 100 new genes that may be essential for cancer immunotherapy to work have been identified using a new CRISPR-based screen... [Read More]

Faster diagnosis hope for mitochondrial disease

14 August 2017 - by Shaoni Bhattacharya

A new approach to genetic analysis may lead to a faster way to diagnose mitochondrial disease... [Read More]

FDA reprimands US doctor trying to commercialise MRT

14 August 2017 - by Georgia Everett

The Food and Drug Administration has warned a US fertility doctor to stop marketing mitochondrial replacement therapy – a technique involving the creation of an embryo with DNA from three people... [Read More]

RNA editing with CRISPR could treat genetic diseases

14 August 2017 - by Emma Lamb and Annabel Slater

Scientists have repurposed CRISPR to target the repetitive RNA sequences responsible for several genetic diseases... [Read More]

Disease-causing mutation edited out of human embryos

07 August 2017 - by Charlotte Spicer

Scientists have published their study confirming they are the first to correct a disease-causing mutation in human embryos using genome editing... [Read More]

Gene therapy skin grafts for obesity and diabetes

07 August 2017 - by Annabel Slater

A proof-of-concept study in mice has demonstrated how skin grafts could deliver gene therapy for obesity and diabetes... [Read More]

Gene therapy reverses muscular dystrophy in dogs in world first

31 July 2017 - by Jenny Sharpe

A safe and effective gene therapy treating Duchenne muscular dystrophy in dogs has been demonstrated... [Read More]

Radio Review: The Inquiry - Is Gene Editing Out of Control?

31 July 2017 - by Cara Foley

The broadcast by BBC World Service is split into four parts, each with an assigned 'expert witness'. The first chapter tackles 'The Language of Life', aiming to elucidate exactly what DNA, genes and genome editing are... [Read More]

Supercomputer overcomes key cancer genomics bottleneck

31 July 2017 - by Rikita Patel

The IBM Watson supercomputer can analyse 160 hours' worth of genomic data in just ten minutes... [Read More]

US lab may have edited human embryos for first time

31 July 2017 - by Charlotte Spicer

Scientists in the US may have successfully used genome editing in human embryos to correct disease mutations, according to a report by MIT Technology Review... [Read More]

75 percent of human genome is junk DNA

24 July 2017 - by Ipsita Herlekar

Almost 75 percent of the human genome is 'junk DNA', suggests a new study... [Read More]

Alzheimer's disease linked to two new genes, and immune response

24 July 2017 - by Caroline Casey

Two new genes which alter the risk of developing Alzheimer’s disease have been identified... [Read More]

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Events using this Glossary Item

Testing, Testing 1, 2, 3: PGS and PGD
13 September 2016 6pm (registration), 6.30pm-8.30pm (discussion) Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH
The Progress Educational Trust's FREE-to-attend event about testing and screening human embryos is taking place TOMORROW EVENING - book NOW. The event will be chaired by Dr Sue Avery, with speakers including Dr Tony Gordon, Dr Christine Patch, James Lawford Davies and Professor Michael Parker...
Risk Assessment: Breast Cancer, Prediction and Screening
08 May 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
The second FREE public event in the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' series...
Relative Risk: Breast Cancer and Genetics
03 April 2014 6.30pm-8.30pm Darwin Lecture Theatre, Darwin Building, University College London, Malet Place, London WC1E 6BT
LAST CHANCE to book for this coming Thursday's FREE event launching the Progress Educational Trust's 'Breast Cancer: Chances, Choices and Genetics' project...
Mutants and What to Do About Them
09 February 2011 7.30pm Conway Hall, Red Lion Square, London WC1R 4RL, UK
The 2011 British Humanist Association/South Place Ethical Society Darwin Day Lecture, given by Armand Marie Leroi...
The Blind-Drunk Mutant Mouse: A Model for Schizophrenia?
19 November 2009 12midday Francis Crick Auditorium, Wellcome Trust Conference Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ, UK
A discussion introduced by Professor Kay Davies, Head of Physiology, Anatomy and Genetics at the University of Oxford...
Techniques and Applications of Molecular Biology
13 July 2009  Department of Biological Sciences, Gibbet Hill Campus, Gibbet Hill Road, University of Warwick, Coventry CV4 7AL
A course for those who wish to develop their understanding of genetic engineering techniques...


Published by the Progress Educational Trust

CROSSING FRONTIERS

Moving the Boundaries of Human Reproduction

Public Conference
London
8 December 2017

Speakers include

Professor Azim Surani

Professor Robin Lovell-Badge

Sally Cheshire

Professor Guido Pennings

Katherine Littler

Professor Richard Anderson

Dr Sue Avery

Dr Elizabeth Garner

Professor Allan Pacey

Dr Anna Smajdor

Dr Andy Greenfield

Philippa Taylor

Dr César Palacios-González

Fiona Fox

Sarah Norcross

EARLY BIRD DISCOUNT
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