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Human Clinical Embryology and Assisted Conception MSc

Glossary

mtDNA (mitochondrial DNA)

Genetic information located within mitochondria, the cell's energy generators, rather than in the nucleus. Mitochondrial DNA is inherited solely through the maternal line, as sperm contribute no mitochondria to the fertilised egg.



Articles using this Glossary Item

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Mitochondrial replacement techniques, Mexico and the legal unknowns

24 April 2017 - by Dr César Palacios-González

It is not every day that we can examine the details of the first use of a new reproductive technology. But the first live birth of a baby following the use of a mitochondrial replacement technique (MRT) in IVF last year gives a window into just this. The case – with procedures carried out in both the US and Mexico – also raises legal questions... [Read More]

Method behind first successful mitochondrial replacement therapy revealed

03 April 2017 - by Helen Robertson

Details of the world's first successful use of mitochondrial replacement therapy in IVF have been published... [Read More]

Infertile couple have baby using mitochondrial donation

23 January 2017 - by Antony Blackburn-Starza

A baby has been born in the Ukraine following the use of an experimental IVF procedure known as mitochondrial donation... [Read More]

Expert panel approve cautious use of mitochondrial donation in the UK

05 December 2016 - by Dr Julia Hill

Scientists advising the HFEA have recommended that the technique of mitochondrial replacement therapy be approved for clinical use in the UK... [Read More]

Autism link to mutations in mitochondria

07 November 2016 - by Helen Robertson

Children with autism spectrum disorder have twice as many harmful mutations in their mitochondrial DNA as their siblings, a study has found... [Read More]

Mitochondrial donation technique used in Ukraine, doctors claim

17 October 2016 - by Ayala Ochert

Two women in the Ukraine are pregnant with babies conceived through mitochondrial donation as a treatment for infertility, according to a report in New Scientist... [Read More]

Mitochondrial replacement therapy and the welfare of the child

17 October 2016 - by Dr Mair Crouch

The announcement of the birth of the first child conceived using mitochondrial donation was unforeseen. Nonetheless, in any country regulation should be required to protect the interests of the child... [Read More]

The Mexican mitochondrial case and moral supremacy

10 October 2016 - by Giulia Cavaliere

The announcement of the first baby born using mitochondrial spindle transfer, one of the two techniques that allow the replacement of faulty mitochondrial DNA, caught the UK scientific and bioethics community by surprise... [Read More]

World's first mitochondrial donation baby born

03 October 2016 - by Dr Julia Hill

In a world first, the birth of a baby boy who was conceived using mitochondrial donation has been reported... [Read More]

The Mexican mitochondrial fiasco

28 September 2016 - by César Palacios González

Dr John Zhang's team have opened a new door in terms of reproductive possibilities, but they may very well be instrumental in closing the assisted reproductive door for many people in Mexico... [Read More]

Event Review: Ethical questions in mitochondrial donation

22 August 2016 - by Dr Reuven Brandt

This transnational symposium on mitochondrial donation covered issues ranging from methodological concerns about the development of policy governing mitochondrial donation, to particular ethical puzzles raised by the implementation of the procedures themselves... [Read More]

Mitochondrial donation case study finally published after 13 years

22 August 2016 - by Dr Özge Özkaya

Chinese researchers say an IVF technique called pronuclear transfer can safely produce a viable pregnancy... [Read More]

Matching mitochondrial and nuclear DNA: Much ado about nothing?

18 July 2016 - by Dr Dusko Ilic

A match of mitochondrial and nuclear genomes apparently affects healthy ageing in mice. But key questions need to be answered before stirring up implications for human mitochondrial replacement therapies... [Read More]

ESHRE 2016: Research highlights

11 July 2016 - by Ayala Ochert

A roundup of research stories from the annual meeting European Society of Human Reproduction and Embryology that hit the headlines this week... [Read More]

Mitochondrial and nuclear DNA mismatch may impact ageing

11 July 2016 - by Dr Julia Hill

The interaction between mitochondrial and nuclear DNA may have implications for health, metabolism and ageing, according to a new study... [Read More]

Sperm self-destruction may lie behind maternal mitochondrial inheritance

04 July 2016 - by Dr Katie Howe

Researchers have identified a gene that, when activated, causes mitochondria inherited from sperm to be destroyed shortly after fertilisation... [Read More]

Mitochondrial donation is safe, study suggests

13 June 2016 - by Dr Özge Özkaya

An extensive study examining human embryos created using mitochondrial donation has demonstrated that the technique does not adversely affect embryo development... [Read More]

Mitochondrial mutations could hamper stem cell therapies

25 April 2016 - by Dr Julia Hill

A study has found that stem cells from older people accumulate high numbers of mitochondrial DNA mutations, which could limit their therapeutic value... [Read More]

Mitochondrial DNA test improves IVF success rates

26 October 2015 - by Jessica Richardson

A test which measures mitochondrial DNA levels in the embryo could help increase IVF success rates, scientists claim... [Read More]

Cutting-edge technology and mitochondrial diseases - where is the limit?

27 July 2015 - by Dr Dusko Ilic

Given the complexity of the technology, costs and risks involved, two recently described mitochondrial 'gene-correction' strategies will probably remain as proof-of-concept studies and are unlikely be of practical use in clinical medicine in the foreseeable future... [Read More]

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