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Glossary

mtDNA (mitochondrial DNA)

Genetic information located within mitochondria, the cell's energy generators, rather than in the nucleus. Mitochondrial DNA is inherited solely through the maternal line, as sperm contribute no mitochondria to the fertilised egg.



Articles using this Glossary Item

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Event Review: Ethical questions in mitochondrial donation

22 August 2016 - by Dr Reuven Brandt

This transnational symposium on mitochondrial donation covered issues ranging from methodological concerns about the development of policy governing mitochondrial donation, to particular ethical puzzles raised by the implementation of the procedures themselves... [Read More]

Mitochondrial donation case study finally published after 13 years

22 August 2016 - by Dr Özge Özkaya

Chinese researchers say an IVF technique called pronuclear transfer can safely produce a viable pregnancy... [Read More]

Matching mitochondrial and nuclear DNA: Much ado about nothing?

18 July 2016 - by Dr Dusko Ilic

A match of mitochondrial and nuclear genomes apparently affects healthy ageing in mice. But key questions need to be answered before stirring up implications for human mitochondrial replacement therapies... [Read More]

ESHRE 2016: Research highlights

11 July 2016 - by Ayala Ochert

A roundup of research stories from the annual meeting European Society of Human Reproduction and Embryology that hit the headlines this week... [Read More]

Mitochondrial and nuclear DNA mismatch may impact ageing

11 July 2016 - by Dr Julia Hill

The interaction between mitochondrial and nuclear DNA may have implications for health, metabolism and ageing, according to a new study... [Read More]

Sperm self-destruction may lie behind maternal mitochondrial inheritance

04 July 2016 - by Dr Katie Howe

Researchers have identified a gene that, when activated, causes mitochondria inherited from sperm to be destroyed shortly after fertilisation... [Read More]

Mitochondrial donation is safe, study suggests

13 June 2016 - by Dr Özge Özkaya

An extensive study examining human embryos created using mitochondrial donation has demonstrated that the technique does not adversely affect embryo development... [Read More]

Mitochondrial mutations could hamper stem cell therapies

25 April 2016 - by Dr Julia Hill

A study has found that stem cells from older people accumulate high numbers of mitochondrial DNA mutations, which could limit their therapeutic value... [Read More]

Mitochondrial DNA test improves IVF success rates

26 October 2015 - by Jessica Richardson

A test which measures mitochondrial DNA levels in the embryo could help increase IVF success rates, scientists claim... [Read More]

Cutting-edge technology and mitochondrial diseases - where is the limit?

27 July 2015 - by Dr Dusko Ilic

Given the complexity of the technology, costs and risks involved, two recently described mitochondrial 'gene-correction' strategies will probably remain as proof-of-concept studies and are unlikely be of practical use in clinical medicine in the foreseeable future... [Read More]

Stem cells could treat mitochondrial disease

20 July 2015 - by Dr Julia Hill

Scientists in the USA have demonstrated how stem cell techniques may benefit people with incurable mitochondrial diseases. The research suggests it might be possible one day to replace diseased tissue in patients affected by the disorders... [Read More]

DNA links Kennewick Man to Native Americans

22 June 2015 - by Dr Julia Hill

New DNA evidence has reignited a longstanding debate over the ownership of a 9000-year-old skeleton, known as Kennewick Man... [Read More]

Genome editing prevents mitochondrial disease in mice

27 April 2015 - by Antony Blackburn-Starza

A gene-editing technique that may prevent mutated mitochondrial DNA from being passed down from mother to child has shown success in an animal study... [Read More]

Can I be my grandchild's mother?

09 March 2015 - by Dr Anna Smajdor

The Daily Mail recently reported that a 59-year-old woman is seeking to give birth to her own grandchild... [Read More]

Leading the way on mitochondrial donation

16 February 2015 - by Professor Frances Flinter

Over the last 30 years I have met some remarkable families, from whom I have learned about the rewards and challenges of caring for relatives with incurable genetic conditions.... [Read More]

Mouse study tests obesity-fertility link

16 February 2015 - by Dr Charlotte Warren-Gash

Obese female mice have lower fertility than healthy weight mice, according to a study led by researchers from the University of Adelaide in Australia... [Read More]

MPs vote overwhelmingly in favour of mitochondrial donation

04 February 2015 - by Sandy Starr

The House of Commons voted by 382 to 128 to pass regulations permitting mitochondrial donation, a majority of 254... [Read More]

Should Parliament vote to allow 'three-parent babies'?

02 February 2015 - by Dr Iain Brassington

It seems to have happened very quickly: it was only in 2012 that the public consultation process about allowing mitochondrial donation to be used on humans was underway; and now – if you'll allow the pun – the first child to have benefitted from them could be conceivable in the next few months... [Read More]

Mitochondrial DNA donors granted anonymity in draft legislation

12 January 2015 - by Dr Rachel Brown

Regulations to legalise and govern the use of mitochondrial donation techniques have been placed before the UK Parliament.... [Read More]

Response to open letter on mitochondrial transfer

24 November 2014 - by Professor Peter Braude and Professor Robin Lovell-Badge

A response to the open letter to the UK Parliament by Dr Paul Knoepfler... [Read More]

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Events using this Glossary Item

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