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Glossary

mtDNA (mitochondrial DNA)

Genetic information located within mitochondria, the cell's energy generators, rather than in the nucleus. Mitochondrial DNA is inherited solely through the maternal line, as sperm contribute no mitochondria to the fertilised egg.



Articles using this Glossary Item

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Mitochondrial donation is safe, study suggests

13 June 2016 - by Dr Özge Özkaya

An extensive study examining human embryos created using mitochondrial donation has demonstrated that the technique does not adversely affect embryo development... [Read More]

Mitochondrial mutations could hamper stem cell therapies

25 April 2016 - by Dr Julia Hill

A study has found that stem cells from older people accumulate high numbers of mitochondrial DNA mutations, which could limit their therapeutic value... [Read More]

Mitochondrial DNA test improves IVF success rates

26 October 2015 - by Jessica Richardson

A test which measures mitochondrial DNA levels in the embryo could help increase IVF success rates, scientists claim... [Read More]

Cutting-edge technology and mitochondrial diseases - where is the limit?

27 July 2015 - by Dr Dusko Ilic

Given the complexity of the technology, costs and risks involved, two recently described mitochondrial 'gene-correction' strategies will probably remain as proof-of-concept studies and are unlikely be of practical use in clinical medicine in the foreseeable future... [Read More]

Stem cells could treat mitochondrial disease

20 July 2015 - by Dr Julia Hill

Scientists in the USA have demonstrated how stem cell techniques may benefit people with incurable mitochondrial diseases. The research suggests it might be possible one day to replace diseased tissue in patients affected by the disorders... [Read More]

DNA links Kennewick Man to Native Americans

22 June 2015 - by Dr Julia Hill

New DNA evidence has reignited a longstanding debate over the ownership of a 9000-year-old skeleton, known as Kennewick Man... [Read More]

Genome editing prevents mitochondrial disease in mice

27 April 2015 - by Antony Blackburn-Starza

A gene-editing technique that may prevent mutated mitochondrial DNA from being passed down from mother to child has shown success in an animal study... [Read More]

Can I be my grandchild's mother?

09 March 2015 - by Dr Anna Smajdor

The Daily Mail recently reported that a 59-year-old woman is seeking to give birth to her own grandchild... [Read More]

Leading the way on mitochondrial donation

16 February 2015 - by Professor Frances Flinter

Over the last 30 years I have met some remarkable families, from whom I have learned about the rewards and challenges of caring for relatives with incurable genetic conditions.... [Read More]

Mouse study tests obesity-fertility link

16 February 2015 - by Dr Charlotte Warren-Gash

Obese female mice have lower fertility than healthy weight mice, according to a study led by researchers from the University of Adelaide in Australia... [Read More]

MPs vote overwhelmingly in favour of mitochondrial donation

04 February 2015 - by Sandy Starr

The House of Commons voted by 382 to 128 to pass regulations permitting mitochondrial donation, a majority of 254... [Read More]

Should Parliament vote to allow 'three-parent babies'?

02 February 2015 - by Dr Iain Brassington

It seems to have happened very quickly: it was only in 2012 that the public consultation process about allowing mitochondrial donation to be used on humans was underway; and now – if you'll allow the pun – the first child to have benefitted from them could be conceivable in the next few months... [Read More]

Mitochondrial DNA donors granted anonymity in draft legislation

12 January 2015 - by Rachel Brown

Regulations to legalise and govern the use of mitochondrial donation techniques have been placed before the UK Parliament.... [Read More]

Response to open letter on mitochondrial transfer

24 November 2014 - by Professor Peter Braude and Professor Robin Lovell-Badge

A response to the open letter to the UK Parliament by Dr Paul Knoepfler... [Read More]

Mitochondrial donation as a clinical option: A response to Ted Morrow

29 September 2014 - by Professor Frances Flinter

Robust debate about the pros and cons of mitochondrial donation is essential, but the clinical reality of mitochondrial disorders is stark. Couples who have lost a child affected by a serious maternally-inherited mitochondrial disorder may have limited reproductive options... [Read More]

Radio Review: Mum and Dad and Mum

22 September 2014 - by Dr Cathy Herbrand

Following a backbench debate in the House of Commons on mitochondrial donation on 1 September, BBC Radio 4 explored some of the issues raised by these high profile techniques aimed at preventing the transmission of mitochondrial disorders... [Read More]

Myth replacement therapy: MPs debate the science of mitochondria

08 September 2014 - by Dr Ted Morrow

The regulatory path to clinical trials of mitochondrial replacement therapy was recently debated in the House of Commons. While scientists are still unsure how genes and genomes cause disease and impact on our physical appearance and personality, there are clearly misconceptions about mitochondrial genetics repeated during the debate that are not supported by current scientific evidence... [Read More]

Government is misleading public about mitochondrial donation, claim scientists

04 August 2014 - by Siobhan Chan

The UK Government has been accused of deliberately misleading the public in order to win approval over its plans to implement mitochondrial replacement techniques in IVF... [Read More]

UK Government plans to legalise mitochondrial replacement for IVF

28 July 2014 - by Rachel Brown

The UK Government has announced that regulations around the use of mitochondrial replacement techniques will be presented to Parliament in the next few months... [Read More]

Event Review: The Ethics of Mitochondrial Replacement Therapy

21 July 2014 - by Professor Vardit Ravitsky, Dr John Appleby, Professor Stephen Wilkinson, Dr Anthony Wrigley and Dr Annelien Bredenoord

Ethical dimensions of the emerging technology of mitochondrial replacement were the focus of a symposium that took place on 25 June at the 12th World Congress of Bioethics in Mexico City.... [Read More]

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