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Glossary

Epigenome

 The total epigenetic (heritable, non-sequence based changes to gene expression) modifications that have been added to one's genome.



Articles using this Glossary Item

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What next for genome editing? Politics and the public

15 January 2018 - by Eleanor Taylor

The ever-expanding limits of human reproduction are creating complex ethical and political challenges. One topic that has generated much contention is the possibility of editing the genome of human embryos... [Read More]

New CRISPR technique reverses diabetes and kidney failure in mice without cutting DNA

11 December 2017 - by Isobel Steer

Scientists in California have used a modified form of the CRISPR/Cas9 genome editing approach to epigenetically treat diabetes, kidney disease and muscular dystrophy in mice... [Read More]

Snuggled babies show lasting changes to their DNA

04 December 2017 - by Sam Sherratt

Close, physical contact – or the lack of it - at an early age may lead to lasting changes to the genes, suggest researchers... [Read More]

Radio Review: The Secrets Inside Your Cells - Epigenetics, Trauma and Ancestry

08 May 2017 - by Dr Avi Lerner

The Human Genome Project, completed in April 2003, greatly improved our ability to study human health and disease. It also provided a deeper insight into our history and evolution as a species. Yet a recent episode of the 'Science Friction' radio show, presented by Natasha Mitchell on Australia’s ABC Radio, delved further into these fascinating topics through the lens of the new and emerging field of epigenetics.

Gene therapy 'reverses ageing' in mice

19 December 2016 - by Sarah Gregory

Gene therapy can reverse the effects of ageing in mice, researchers claim... [Read More]

Epigenetic sperm test sheds light on male infertility

31 October 2016 - by Dr Ashley Cartwright

The US start-up Episona has produced an epigenetic sperm test, which it claims can determine whether sperm will produce 'good' or 'poor' quality embryos... [Read More]

Vitamins A and C erase cell memory to create stem cells

17 October 2016 - by Dr Rosie Gilchrist

Vitamins A and C help to convert adult cells into stem cells by performing a cell 'reset', erasing their epigenetic memory, a study has found... [Read More]

Hispanic longevity linked to epigenetics

30 August 2016 - by Dr Ashley Cartwright

Researchers in the US have found that Hispanic individuals age slower than people from other ethnic backgrounds... [Read More]

Event Review: The Francis Crick Prize Lecture 2015

21 December 2015 - by Isobel Steer

If you'd like to learn more about epigenetics, or just watch a masterly science presenter at work, look to 2015 Francis Crick Prize winner Professor Rob Klose... [Read More]

Epigenetic changes in sperm linked to obesity in offspring

07 December 2015 - by Jessica Richardson

Danish researchers have identified that weight gain and loss can result in different epigenetic markers in sperm, suggesting a possible explanation for why children of obese fathers are more prone to obesity themselves... [Read More]

Obesity findings set precedent for GWAS research

07 September 2015 - by Dr James Heather

Recent findings linking the FTO gene to adipose cell energy use not only revealed a molecular mechanism that contributes to obesity, but they are also an exemplar of how genome-wide association study findings can make the journey to clinical relevance... [Read More]

Sperm DNA changes linked to autism

20 April 2015 - by Meghna Kataria

A study has found a link between DNA methylation levels in sperm and an increased risk of autism in children, indicating that epigenetic changes could explain why the disorder appears to run in families.... [Read More]

Masters of the genome – epigenomic 'map' revealed

23 February 2015 - by Meghna Kataria

Scientists have unveiled a map of the human epigenome - the suite of molecular controllers which turn genes on and off in every human cell... [Read More]

Epigenetic changes linked to Alzheimer's

26 August 2014 - by Claire Downes

Researchers have identified a connection between DNA methylation and Alzheimer's disease, gaining a further understanding into the underlying causes of this neurodegenerative condition.... [Read More]

Course Review: Epigenetic Control of Gene Expression

30 September 2013 - by Marco Narajos

There is definitely great scope for expansion in genetics education through online courses, but these should be tailored towards the student's pace, however leisurely that might be... [Read More]

Autism mechanism goes beyond genes

29 April 2013 - by Dr Daniel Grimes

A study on identical twins with distinct autistic traits suggests that epigenetic factors may be important in understanding how the neurological disorder develops... [Read More]

The mother isn't always certain: Irish surrogacy case leads the way

11 March 2013 - by Dr Kirsty Horsey

Once upon a time, motherhood was certain. It was proved by giving birth. The Latin maxim 'mater semper certa est' that told us so was irrefutable. Whether or not that was ever actually true, it has for a long while been biologically, as well as socially, questionable.... [Read More]

TV Review: Science Club - Reproduction

19 November 2012 - by Dr Lucy Spain

Have you ever wondered how to extract your own DNA? Or if there's a scientific theory behind what makes the most attractive partner? If so then Dara O'Briain's Science Club is the (only?) programme for you.... [Read More]

Identical twins start to differ in the womb, study shows

23 July 2012 - by Dr Rebecca Hill

Despite sharing the same womb, identical twins are born with different alterations to their DNA that can affect the activity of individual genes... [Read More]

Epigenetics: responding to life by switching genes on and off

07 December 2009 - by Dr Aarathi Prasad

Session 3 of the Progress Educational Trust's annual conference (PET), held on Wednesday 18 November 2009 at Clifford Chance, was chaired by Professor Dian Donnai,Professor of Medical Genetics at the University of Manchester, and started with a talk by Karen Temple, Professor of Medical Genetics and Honorary Consultant in Clinical Genetics at the University of Southampton and Wessex Clinical Genetics Service. Professor Temple gave an intriguing talk on the influence of parent... [Read More]

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