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Gene variants linked to childhood obesity discovered

16 April 2012

By Oliver Timmis

Appeared in BioNews 652

Two new genetic variants that could increase the risk of childhood obesity have been identified in the largest ever genome-wide study of the disease.

In contrast to previous studies looking at extreme forms of obesity, this research focused on common childhood obesity, said Dr Struan Grant, study author and Associate Director at the Center for Applied Genomics at The Children's Hospital of Philadelphia.

Obesity is unlikely to be caused purely by genetics, but the presence of these two gene variants, which Dr Grant says are 'very common in the population', may increase the likelihood of becoming obese in the early years of life. He suggests the alterations may function in the intestinal tract and influencing the activity of natural bacteria.

The study, published in Nature Genetics, combined data from 14 studies conducted in the USA, Canada, Australia and Europe. In total, the genomes of 5,530 obese children and 8,318 non-obese controls were analysed.

They identified two variants - one near a gene on chromosome 13, and one near a gene on chromosome 17.

'Certain kids, even in the best environments, are prone to be obese because of genetics. Actually identifying the genes really helps', said Karen Winer, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development in an interview with Time Healthland.

However, the gene variants are not guaranteed to make a child obese; while they may increase the risk, weight gain is still thought to be largely due to environmental factors. As such, researchers advise that a healthy lifestyle, exercising and eating the right foods is still the best way to avoid obesity.


28 October 2013 - by Dr Rachel Brown 
A number of rare mutations in a gene that helps regulate how the body burns calories has been linked to an increased appetite and childhood obesity, according to a study from the University of Cambridge...

26 March 2012 - by Dr Kimberley Bryon-Dodd 
A mutation in a gene linked to obesity causes mice to eat up to 80 percent more than normal...
19 March 2012 - by Dr Linda Wijlaars 
A gene known to protect from cancer might also prevent obesity, scientists say. The researchers had set out to search for a link between the Pten gene and a longer lifespan in mice, but to their surprise, a double dose of the gene also led the mice to be thinner than their normal counterparts...
07 November 2011 - by Dr Marianne Kennedy 
When it comes to our weight, there is no need to wallow in the gene pool. Scientists have found that physical activity lessens the link between genes and obesity...
23 May 2011 - by Dr Kimberley Bryon-Dodd 
Scientists say they have found a 'master regulator' gene, KLF14, which controls how active some fat metabolism genes are in your fat cells....

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