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Clarification: Hope for parents with mitochondrial diseases

15 February 2008

By BioNews

Appeared in BioNews 445

In last week's BioNews we published an article about research into possible new treatments for mitochondrial disorders, in which we stated that: 'Sperm do not contribute any mitochondria to the embryo (as they are all present within the tail, which falls off after fertilisation) and, consequently, children inherit all their mitochondrial genes from their mother'.

It has been pointed out to us that it is not entirely correct to state that all of a sperm's mitochondria are present in the tail. Whilst it is true that 'sperm do not contribute any mitochondria to the embryo and, consequently, children inherit all their mitochondrial genes from their mother' it is has been known for a decade that some paternal mitochondria do get into the egg but are selectively destroyed - while this is an interesting biological phenomenon in its own right, it does not alter the maternal inheritance pattern of mitochondrial mutations.

 

SOURCES & REFERENCES

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

06 June 2011 - by Marianne Neary 
Women at risk of passing on mitochondrial disease to their children could use PGD to give birth to an unaffected child. The scientists at Maastricht University Medical Centre in the Netherlands claim their work has the potential to prevent the transmission of mitochondrial diseases...[Read More]
14 March 2011 - by MacKenna Roberts 
Health Secretary, Andrew Lansley has asked the Human Fertilisation and Embryology Authority (HFEA) to convene an expert group 'to assess the effectiveness and safety' of a fertility treatment that would enable children to be born without potentially devastating, incurable mitochondrial diseases.
19 April 2010 - by Ruth Pidsley 
A team of researchers at Newcastle University in the UK has been successful in attempts to transfer genetic material from one newly fertilised human egg to another without carrying over the egg's mitochondria (the energy-producing structures of a cell)...[Read More]
15 November 2009 - by Dr Rebecca Robey 
A controversial new technique to improve the quality of eggs from older women undergoing IVF is being developed by Japanese scientists. Because the procedure involves using eggs from two women to create a single viable egg for fertilisation, it has sparked a media furore over the potential creation of what have been inaccurately dubbed 'three-parent embryos'....[Read More]
01 September 2009 - by Adam Fletcher 
A variation of somatic cell nuclear transfer (SCNT), reported online in the journal Nature, could be used in humans to allow women with a certain group of incurable inherited conditions - known as mitochondrial disorders - to have children without passing on the condition. Because the technique, developed by Dr Shoukhrat Mitalipov and team from the Orgeon National Primate Research Centre, US, involves the the sperm from one monkey and two eggs from different monkeys...[Read More]

11 February 2008 - by Dr Rebecca Robey 
Scientists at the University of Newcastle are developing a technique that they hope will enable women with a group of devastating hereditary illnesses - known as mitochondrial diseases - to have children without passing on their genetic disorders. Because the method involves sperm from one man and two eggs...[Read More]

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