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Short people 'short' on genes

28 November 2011

By Dr Rebecca Hill

Appeared in BioNews 635

Short people can blame deleted sections of DNA for their diminutive stature, according to a study looking at variations in the genomes of over 12,000 people.

The US group from Children's Hospital Boston noticed a link between smaller people and the amount of genetic material missing in their genomes.

It is widely accepted that height is heritable, but 'despite tremendous recent progress in finding common genetic variants associated with height, thus far these variants only explain about 10 percent of the variation in adult height', explains lead author Dr Joel Hirschhorn.

He believes about half of height variation could be accounted for by differences in the amount of DNA present at particular points in the genome. To investigate, his team looked at specific changes known as copy number variants (CNVs). These are alterations causing certain regions to have either too much or too little DNA. While everyone will have some of these abnormalities in their genomes, some people have millions; and some areas of DNA are more commonly affected than others.

'To investigate whether CNVs play a role in short or tall stature, we conducted a genome-wide association study of copy number in a cohort of children... and we observed an excess of rare deletions in children with short stature', co-author Dr Yiping Shen said.

When the team carried out the same analysis on a larger population they again found an excess of deletions in shorter people. According to the Telegraph, for every million individual deletions, people lost one eighth of an inch in height.

They write in their report, published in the American Journal of Human Genetics, that these findings were not due to any known gene deletion syndromes. They could not, however, make a link between CNVs and tall stature.

'Our findings strongly support the hypothesis that increasing burden of lower frequency deletions can lead to shorter stature, and suggest that this phenomenon extends to the general population', commented author Dr Andrew Dauber.


06 February 2017 - by Jamie Rickman 
A large international study has uncovered 83 rare genetic variants that can significantly affect a person's height...
15 May 2012 - by Dr Lux Fatimathas 
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20 February 2012 - by Dr Rosie Gilchrist 
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11 July 2011 - by Daniel Malynn 
Adam Wishart's documentary charted his personal journey to discover the secrets hidden in his genes. After his mother's death from breast cancer, Adam wanted to discover whether he too is genetically at risk of developing the disease. Looking at his immediate family history, he found seven of his mother's 14 brothers, sister and cousins died from cancer. Adam's mother, aunt and grandmother all had breast cancer...
09 May 2011 - by Dr Lux Fatimathas 
British scientists say they have discovered a link between an individual's satisfaction with life and the type of 5-HTT gene they carry. The 5-HTT gene encodes a transporter for the brain chemical serotonin, which has previously been associated with regulating mood. Individuals carrying the long version of the gene were shown to...
08 March 2010 - by Professor John Dupré 
It's hard to avoid press stories about 'the gene for' something, because they appear with monotonous regularity. On the day I wrote this, the media reported the discovery of a 'gene for longevity'. The story clearly implied that lifespan is pretty much fixed at conception - contradicting stories elsewhere in the paper...

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