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Human embryos donated for research: a gift that goes on giving

16 October 2017

By Dr Kay Elder

Kay Elder is senior research scientist at Bourn Hall Clinic

Appeared in BioNews 922

Successful IVF treatment crucially depends on the culture systems used, which must provide an optimal environment for healthy embryo development; yet most embryos arrest in culture or fail to continue development after implantation. Human embryo culture has long been based upon research into animal systems, the mouse model in particular. While culture systems have been refined over the past 30 years through clinical experience with human IVF embryos, many quality control protocols still involve testing materials in a mouse embryo culture system.

During the past decade, significant advances in biological techniques have provided increasingly sophisticated analysis of the molecular and genetic mechanisms regulating the health of gametes and embryos: a window has been opened onto previously inaccessible pathways of embryonic development. Over the past five years, experiments carried out using cryopreserved human embryos donated for research have revealed clear differences in early development between mouse and human embryos (Kujik et al. 2012; Niakan et al. 2012; Roode et al. 2013; Niakan & Eggan 2013; Huntriss et al. 2013; Menezo et al., 2013; Holubcova et al., 2015; Blakely et al., 2015; Boroviak et al. 2015; Petropoulos et al. 2016; Fogarty et al., 2017).

Every embryo generated during an IVF treatment cycle is used first and foremost for treatment; after fresh embryo transfer, surplus healthy embryos are frozen for future treatment. If these are no longer required, due to completion of family or other reasons, they can be donated for approved research projects. These surplus embryos are an immensely valuable and unique resource.

Further detailed research could potentially improve clinical IVF success rates, ultimately helping more patients to achieve their goal of giving birth to a healthy baby. However, such research requires specialised facilities and cutting-edge technology in academic centres with dedicated research staff – a situation that is beyond the scope of the majority of clinical IVF services.

At Bourn Hall Clinic in Cambridge, surplus embryos are cryopreserved in 40-50 percent of fresh cycles. On each anniversary of the date of freezing, patients are asked to inform the Clinic regarding their options for these embryos. Couples can choose to continue storage for future treatment, donate them to other couples trying to conceive (subject to strict criteria), ask the clinic to dispose of them (allow to perish: ATP), or donate them for research into early embryo development. In order to offer the option for research, we have established close collaborations with several university departments, and the Francis Crick Institute (FCI) in London, a biomedical facility dedicated to understanding the fundamental biology underlying health and disease. The research potential of these donated embryos is maximised in projects at these institutions.

At the end of every month, an average of 80-100 letters are sent to patients with embryos in storage, with an annual storage consent form that must be signed to confirm the patients' wishes regarding their embryos. Approximately 80 percent of the returned forms request continued storage; 10 percent indicate 'ATP', and another 10 percent choose the option of donating their embryos to research. Over 90 percent of patients who are sent research information return a signed consent form, and 80-91 percent of these patients have at least one healthy child. Around 25 percent have two or even three healthy children (twins plus singleton, or three singletons). Surplus embryos which resulted from these successful cycles have very high viability potential, and are particularly valuable for research.

Having completed their family, couples are often grateful for the opportunity to 'give something back'. They often comment that they recognise the importance of continued fundamental research to improve IVF techniques for other couples undergoing treatment in the future. Patients who have suffered the distress of repeated failure, or early or late miscarriages sometimes also choose to discontinue treatment and donate their remaining embryos to research.

Couples receive information about accessing our counselling services, about research into 'Understanding the biology of human preimplantation embryos, gametes and stem cells', and a comprehensive consent form to be signed by both partners. The research information and consent form were carefully composed by a multi-disciplinary team including policy and legal advisers, and extensively reviewed by ethics committees and the HFEA, Human Fertilisation and Embryology Authority. In addition to signing the consent document, several different paragraphs in the form must be acknowledged with both partners' initials, and the documents also confirm that all donated embryos will be used only in projects licensed by the HFEA, with strict regulatory oversight and review.

Every embryo donated for research makes an immensely valuable contribution to medical science, and is greatly appreciated. The information gained from the scientific studies will not only lead to optimisation of human embryo culture systems to improve fertility treatment, but also help in understanding the origin of defects and to avoid miscarriage. There is also the potential for developing new research tools that can lead to cures for many serious disorders.

The current landscape of scientific research is such that tremendous advances in the understanding of early development and disease processes are now a realistic possibility. In the UK, we are fortunate to have the HFEA as a governing body to ensure human embryos can be donated to research projects that have been approved and licensed after full ethical and legal consideration and review. The majority of UK IVF clinics will inevitably have embryos surplus to treatment in frozen storage. Giving patients the option of donating their surplus embryos to research projects transforms our understanding of human biology.

SOURCES & REFERENCES
Development | 2015
 
Developmental Cell | 2015
 
Nature | 2017
 
Science | 2015
 
European Journal of Human Genetics | 2013
 
Development | 2012
 
Journal of Assisted Reproductive Genetics | 2013
 
Developmental Biology | 2013
 
Development | 2012
 
Cell | 2016
 
Developmental Biology | 2013
 

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

06 November 2017 - by Dr Lucy Frith, Dr Steve Lui and Professor Eric Blyth 
Once a couple or individual has finished their fertility treatment, the question of what to do with any remaining frozen embryos is often perceived as a difficult decision. There are, broadly, four options to choose from...
06 November 2017 - by Eleanor Taylor 
As a 33-year-old single woman, who also happens to work in a fertility clinic, babies are unsurprisingly never far from my mind. I spend a lot of time wondering whether I should freeze my eggs. A lot...

13 March 2017 - by Dr Dusko Ilic 
The regulatory mechanisms governing organ development are, in general, poorly defined. To recreate the complex processes involved in organ growth and maturation, scientists have started fiddling with three-dimensional (3D) cell culture...
30 August 2016 - by Helen Robertson 
A study comparing two common IVF media used by fertility clinics has found different outcomes in implantation success rates and birth weight...
06 June 2016 - by Anneesa Amjad 
The Dutch government is planning to change the law to allow for the creation of human embryos for research...
04 April 2016 - by Helen Robertson 
The presence of genetic abnormalities in cells taken from the placenta at the early stages of pregnancy does not necessarily mean that a baby will be born with a genetic disorder, a study in mice suggests....

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