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King's College London - Health: More than a medical matter





Fertility treatment success may depend on season

20 September 2010

By Gozde Zorlu

Appeared in BioNews 576

Higher fertilisation rates have been found in women undergoing IVF in spring, according to new research presented at the World Congress of Fertility and Sterility last week.

The study analysed 1932 patients undergoing ICSI (intracytoplasmic sperm injection) - 435 patients in winter, 444 in spring, 469 in summer and 584 in autumn. While the percentage of developing eggs, high-quality embryos, implantation, and pregnancy rates did not differ among the group, the fertilisation rate was significantly higher during the spring.

Those who had treatment in March, April or May were 1.5 times more likely to conceive than at any other time of the year. The success rates were: 67.9 per cent in winter, 73.5 per cent in spring, 68.7 per cent in summer and 69 per cent in autumn. All the patients in the study came from one clinic - Sao Paulo's Assisted Fertilisation Center.

Dr Daniela Braga, head researcher at the centre and leader of the study, said: 'This work shows that IVF cycles may have a better outcome during the spring. In practical terms this may mean that if you are having real difficulty in conceiving, it may be better to have an assisted reproduction cycle during this season'.

Dr Braga believes the increase in light in spring could trigger women's bodies to produce higher levels of estradiol, a hormone important for fertilisation of the egg and development of the embryo. Through blood samples taken from the participants in the study, higher levels of estradiol were detected in spring.

But experts say the findings do not suggest women should wait until the spring to undergo fertility treatment, as this may be risky. Dr David Keefe, Chair of Obstetrics and Gynaecology at the NYU Langone Medical Centre in New York City, said: 'First, when we do in vitro, we're already overriding the whole system and the hormones that turn on reproduction'.

'And, second, species that have a longer gestation, such as humans, have typically bred when the days are getting shorter, and they [the study authors] found the opposite here', he added. 'In addition, humans aren't as controlled or hardwired to environmental changes any more. We live in artificial lights, and control the temperature and humidity, so many cues that would trigger breeding, we control all the time. We've insulated ourselves against environmental changes'.

Dr Braga highlighted the success of IVF, no matter what the season: 'Despite the better results obtained in spring, it is important to highlight that assisted reproduction techniques are effective regardless of the season in which the treatment is being performed', she said.

The Daily Mail reports the study supports findings from previous research at the Countess of Chester Hospital and Liverpool Women's Hospital, which found 20 per cent of IVF cycles from May to September resulted in a successful pregnancy, compared to 16 per cent for the remainder of the year.

The study was initially reported in a press release from the World Congress of Fertility and Sterility. BioNews asked John Parsons, a Progress Educational Trust trustee and retired gynaecologist, to comment on the study, using information given in the press release.

He said about the release: 'The study appears to be a retrospective analysis of data. It is not clear over what time period [the research was done], but I suspect over a single year, or whether there was more than one clinic involved'. Using information in the release alone, he felt unable to comment upon or draw any conclusions from the study.

 

SOURCES & REFERENCES
Daily Mail | 14 September 2010
 
New Scientist | 16 September 2010
 
Health24.com | 15 September 2010
 

RELATED ARTICLES FROM THE BIONEWS ARCHIVE

07 March 2011 - by Leo Perfect 
Researchers from the University of Western Australia have published a study suggesting IVF effectiveness could be improved by undergoing more cycles.... [Read More]
14 February 2011 - by Marianne Neary 
New research suggests that women from ethnic minority backgrounds may have lower success rates with fertility treatment.... [Read More]
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08 November 2010 - by Victoria Kay 
Women who have not conceived after two cycles of IVF (in vitro fertilisation) may face reduced success rates if electing to undergo further cycles, according to a new study. The research is preliminary and many factors which may affect IVF success, such as the age and weight of the women, were not taken into account.... [Read More]

13 September 2010 - by Dr Charlotte Maden 
British women are prepared to spend an average of 15,000 in order to conceive, a survey has shown, with one in ten willing to spend over 50,000 on fertility treatment... [Read More]
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24 May 2010 - by Victoria Kay 
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